Don't take genetic testing as a fortune teller

2022-08-26
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Don't take gene testing as a "fortune teller"

gene testing is a high-tech technology, but it's not like we think that with this technology, you can rest easy. Commercial genetic testing can only provide the risk probability of individual susceptible genes, and can not "cure all diseases". We should treat genetic testing rationally

in recent years, "gene" has become a social hot word. Some commercial institutions have issued slogans such as "decoding the secrets of life, predicting future health" and "genetic testing, the best gift for relatives", and launched products such as the so-called gifted genetic testing, genetic examination package, cosmetic genetic testing, and familial disease risk prediction. Then, with the help of genetic testing, can we really accurately predict diseases, and even predict the talent of children? What problems will genetic testing bring when it is mixed with profits

first of all, commercial genetic testing only provides the risk probability of individual susceptibility genes, and cannot "cure all diseases"

from a technical point of view, gene detection is a technology that uses human blood or body fluid to detect personal DNA. Most human diseases are polygenic diseases, which are usually the product of multiple genetic variations and the influence of environment, lifestyle and other factors. The existing genetic testing has found more than 1000 human disease genes, but most of them are single gene diseases. Therefore, the test results are mostly about the description of the subject's future disease possibility, which is generally expressed by "high", "medium", "low" and other risk probabilities. For example, a subject has a susceptibility gene for Alzheimer's disease, and the risk probability of suffering from Alzheimer's disease in the future is moderate. The relevant explanation is that the subjects are five times more likely to suffer from Alzheimer's disease than the normal population

there may be no people without disease genes in this world. However, genetic testing alone cannot accurately determine whether a person is ill, when he is ill, what disease he is ill, how the disease is induced, or what kind of talent he has. Scientists have constantly reminded the public that genetic testing has early warning value for diseases, but we should not deify it too much, let alone regard it as a "fortune teller", and we should be cautious and rational. As for the prediction of "genius", I'm afraid it's a little more fanciful

secondly, the psychological impact of genetic testing on subjects should not be underestimated

people pursue gene testing, one of the main purposes is to find disease genes as soon as possible, carry out early prevention, and improve the quality of life. The problem is that even if the source of many human genetic diseases is found through genetic testing, it is difficult to effectively treat them with existing medical means, or the treatment cost is huge and individuals cannot afford it. In this case, can individuals afford this cruel "disease prediction"

there is also a situation that some individuals do not necessarily get sick even if they carry certain disease genes. Therefore, the so-called "disease prediction" may unreasonably increase the psychological pressure of subjects. A foreign survey on subjects of genetic testing shows that 40% of people need psychological treatment after receiving genetic testing; There are also a few people who have depression and suicidal tendencies after knowing their genetic disease risk. Therefore, there are regulatory requirements in the United States that people under the age of 18 cannot do genetic testing for Alzheimer's disease

finally, the disclosure of genetic privacy may lead to genetic discrimination and new social contradictions

human genetic information is a kind of special personal information, which covers sensitive information such as physical traits, behavior, personality characteristics and disease susceptibility, and is closely related to human genetic activities. It can be said that genetic information constitutes the most basic privacy of individuals

the existing practice shows that the disclosure of genetic privacy will cause some institutions and enterprises to deprive or exclude some people's resin casting performance experimental method gb/t 2567 ~ 2571 ⑴ 995 rights, benefits or machines in the workplace and community according to the results of personal genetic testing, accounting for 19% of the total income of polymer 3D printing. In 1992, the operation number media in the United States reported that 41 carriers of defective genes could not get personal and health insurance. In 2001, the North Santa Fe Railway Company of the United States took the results of the genetic test to completely clean the fuel tank as the basis for hiring employees, which triggered a strong response from the society. This reminds us from one side that if the commercial application of genetic testing lacks perfect ethical norms and institutional ethics, it is very likely to cause the abuse of technology and cause new social injustice and social problems

to avoid the social and ethical risks of gene testing technology, we need to carry out scientific response as soon as possible. The most critical measure is to establish a good access system and testing norms. What institution is qualified for genetic testing? Which department is responsible for supervision? How does the management department supervise the relevant testing institutions? Where can genetic testing be applied? How to prevent the risk of commercial institutions obtaining personal genetic information for profit? Such problems need to be considered early and scientifically standardized

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